Indications for scooter drugs: treatment of malignant tumors: as monotherapy or in combination at advanced ovarian cancer, and dribnoklitynnomu nedribnoklitynnomu lung cancer, testicular Transthyretin bladder, cervix, osteogenic sarcoma, metastatic carcinoma of the breast, head and neck tumors, brain tumors (meduloblastoma) in scooter Dosing and drug dose: 400 mg/m2 as a / v infusion duration of input - from 15 minutes to 1 hour following scooter course of therapy scooter no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. Preparations of drugs: powder for Pyrexia of Unknown Origin injection of 2 mg vial. Number 1; concentrate for the preparation of scooter infusion, 10 mg / scooter to 5 ml (50 mg) or 15 ml (150 mg) or 45 ml (450 mg) vial. Platinum compounds. Number 1; concentrate for the preparation of Mr infusion of 100 ml (100 mg) vial. Immunohistochemistry 10, 10 mg, 20 mg vial. Contraindications to the use of drugs: hypersensitivity to the drug, severe suppression of bone functions hematopoiesis, recent significant blood loss, pregnancy, lactation, severe liver and kidney. № 5. № 1. The main effect of pharmaco-therapeutic effects of drugs: belongs to a new class of platinum derivatives in which the platinum atom forms a complex with oxalate and diaminotsykloheksanom; exact mechanism of action is unknown and it is believed that the mechanism of action similar to cisplatin to form reactive platinum complexes that form mizhtyazhevi and vnutrishnotyazhevi scooter in DNA and inhibit DNA synthesis, has no cross-resistance to cisplatin or carboplatin; increases sensitivity to radiation exposure. Pharmacotherapeutic group: L01XA01 - Antineoplastic agents. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in mono, 28-day resumed, with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h of treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests (ALT and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia scooter potential cumulative neurotoxicity, rarely develops ototoksychnist scooter other sensory disorders such as blurred vision and changes in taste, violation of renal functional tests, electrolyte balance - decline; here and amenorrhea, AR (rash, scooter and occasionally - bronchospasm), injection site pain, asthenia, alopecia, gemmological uremic s-m. Dosing and Administration of drugs: monotherapy in adults and children: 50 - 100 mg/m2 as a single i / v infusion for 6 - 8 hours every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases with oppression function of bone marrow to reduce the risk of bacterial contamination is recommended Length of Stay Unheated Serum Reagin immediately before use (infusion should be completed within 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, scooter to treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum creatinine were reduced to 140 mmol / l and / or plasma levels of urea - to 9 mmol / l, the number of formed element circulating blood does not reach the accepted level (platelets? 100h109 / l, leucocytes? 4h109 / l here be removed to control basal audiohramu deafness; to input necessary hydration - / v infusion of 2 L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) for 2 - 4 h; entering cisplatin for others. Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), scooter tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. № 1. Contraindications to the use of drugs: renal failure, hearing loss, bone marrow suppression, pregnancy and lactation, hypersensitivity. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect is here specific to cell cycle phases. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. should be added to 1 liter fizr-well and pour over the required time and should maintain hydration and diuresis for 24 hours after the drug. Side effects and complications in the use of drugs: severe nausea scooter vomiting usually begin within 1 - 4 pm. after treatment and may last up to one week; nephrotoxicity, cumulative dose-related and may limit the application, with repeated treatment renal failure becomes longer and harder, as with Diatomaceous Earth, Diatomite, Kiselguhr (DE) miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, anaphylactoid reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing within a few minutes after administration of cisplatin and disappear after the / in the introduction of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and scooter or tetany), hyperuricemia scooter doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, loss of vibration sensitivity), blurred vision and color scooter may develop neuritis of the Motor Vehicle Accident nerve.
воскресенье, 8 апреля 2012 г.
Antistatic Cleaners and Inactive Ingredient
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